Targetome

Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).

Receptor-guided proteolysis at the host-gut microbiota interface: insights from the Bacteroides fragilis toxin-claudin-4 axis

Danni Tong, Weiwei Zheng, Frank J. Gonzalez, Yuhong Luo

DOI: 10.48130/targetome-0026-0046

The neuro-immune-metabolic network in ischemic stroke: mechanisms and therapeutic targeting of brain-peripheral organ crosstalk

Jinmei Li, Jingye Yao, Jinnuo Zhao, Yuanyuan Lai, Wei Zhou, Wen Gao, Yi Li

DOI: 10.48130/targetome-0026-0045

Spatiotemporal specificity of H3 receptor signaling: from molecular basis to precise regulation of brain function

Yanrong Zheng, Zhuowen Fang, Zhong Chen

DOI: 10.48130/targetome-0026-0044

Exposure to multiple drugs with actionable pharmacogenetic biomarkers among older adults in China: a retrospective analysis

Xiaowen Hu, Yuxuan Zhao, Xue Wang, Gengchen Wang, Xinyi Zhang, Wenliang Dong, Luwen Shi, Christine Y. Lu, Xiaodong Guan, Xiaoyan Nie

DOI: 10.48130/targetome-0026-0043

Dual Cognition Improving Mechanisms of Huperzine A in Vascular Dementia Mice via Neurometabolic Regulation

Yangfan Zhang, Zemin Li, Ruizhe Nie, Haoqian Wu, Jiajie Li, Xiaoying Cai, Youying Zhang, Xuan Lin, Ruiqi Duan, Shunyuan Liu, Ping Zhou, Yu Fu, Haiping Hao, Xiao Zheng

DOI: 10.48130/targetome-0026-0042

KCC2 neuromodulation remodels metabolic and morphofunctional signatures across the neuromuscular axis in mdx mice

Alex D Assis, Iola MF Duarte, Alessandra Sussulini, Alexandre LR Oliveira

DOI: 10.48130/targetome-0026-0041

Design and delivery of targeting chimeras therapeutics in managing central nervous system disorders

Shuo Liu, Wei Xu, Mengxi Wang, Zhen Mao, Jianping Zhou, Xiaochen Gu, Guochen Han, Yang Ding

DOI: 10.48130/targetome-0026-0028

Drug resistance-driven cytokine alterations in the immunosuppressive microenvironment of colorectal cancer

Yingying Shao, Zewen Zhang, Yu Wang, Chunze Zhang, Erwei Liu, Haiyang Yu

DOI: 10.48130/targetome-0025-0012

Molecular characteristics, regulatory mechanisms, and targeted therapeutic strategies of Claudin18.2 in pancreatic cancer

Xiaoying Pan, Xinyuan Cao, Jiaojiao Ni, Jieer Ying

2026, 2(4): e034. DOI: 10.48130/targetome-0026-0033

An AI-integrated pharmacophore and transcriptomic framework for rapid discovery of therapeutic leads for ischemic stroke

Jinran Li, Zheng Zhou, Yongjun Zhao, Sai Liu, Long Chen, Yiting Shi, Haotian Li, Yuan Sun, Tingting Yao, Wei Jiang, Qun Xue, Zheying Zhu, Guangji Wang, Xinuo Li

2026, 2(4): e035. DOI: 10.48130/targetome-0026-0034

A photo-clickable, chain-terminating NAD⁺ analogue enables systematic profiling of the PAR-interacting proteome under oxidative stress