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Receptor-guided proteolysis at the host-gut microbiota interface: insights from the Bacteroides fragilis toxin-claudin-4 axis
Danni Tong, Weiwei Zheng, Frank J. Gonzalez, Yuhong Luo
2026, 2(5): e046. DOI: 10.48130/targetome-0026-0046
Targeting PTPN2-mediated dephosphorylation destabilizes c-MYC and suppresses acute myeloid leukemia survival
Wenbin Kuang, Dawei Wang, Mingge Song, Jianing Liu, Jiaxing Li, Wenmu Wang, Anyan Chen, Ya Chen, Jiayu Ding, Liping Wang, Wanjian Gu, Yibei Xiao, Xiao Wang, Peng Yang
2026, 2(5): e053. DOI: 10.48130/targetome-0026-0052
The tumor targetome in CAR-T and TCR-T cell therapy
Shijing Wang, Bin Sun, Sandhya Rai, Xinyi Yang, Sariya Banday, Abdullah Memon, Tyce Kearl, Peiman Hematti, Nirav Shah, Jing Dong, Subramaniam Malarkannan, Siegfried Janz, Anita D'Souza, Binod Dhakal, Joseph Zenga, Fumou Sun
2026, 2(5): e051. DOI: 10.48130/targetome-0026-0050
The neuro-immune-metabolic network in ischemic stroke: mechanisms and therapeutic targeting of brain-peripheral organ crosstalk
Jinmei Li, Jingye Yao, Jinnuo Zhao, Yuanyuan Lai, Wei Zhou, Wen Gao, Yi Li
2026, 2(5): e047. DOI: 10.48130/targetome-0026-0045
Dual cognition-improving mechanisms of huperzine A in vascular dementia mice via neurometabolic regulation
Yangfan Zhang, Zemin Li, Ruizhe Nie, Haoqian Wu, Jiajie Li, Xiaoying Cai, Youying Zhang, Xuan Lin, Ruiqi Duan, Shunyuan Liu, Ping Zhou, Yu Fu, Haiping Hao, Xiao Zheng
2026, 2(5): e043. DOI: 10.48130/targetome-0026-0042
Lipotoxicity in MAFLD/MASH: cellular mechanisms and targetable nodes
Joseph Tawai, Kairan Zhou, Jing Xiong
2026, 2(5): e049. DOI: 10.48130/targetome-0026-0047
Spatiotemporal specificity of H3 receptor signaling: from molecular basis to precise regulation of brain function
Yanrong Zheng, Zhuowen Fang, Zhong Chen
2026, 2(5): e045. DOI: 10.48130/targetome-0026-0044
Chinese Medicine for the treatment of pancreatic cancer by targeting the tumor microenvironment: mechanistic insights and therapeutic potential
Le-Ran Xue, Yu-Lin Wu, Zhi-Xiu Lin, Yan-Fang Xian
2026, 2(5): e050. DOI: 10.48130/targetome-0026-0049
Covalent targeting of IP receptor and PTEN mediates pyrrolizidine alkaloid-induced pulmonary hypertension
Caibin Zhang, Xiaokai Guo, Tianyang Huang, Yujian Fan, Yisheng He
2026, 2(5): e048. DOI: 10.48130/targetome-0026-0048
Claudin-4 as the molecular gateway to Bacteroides fragilis toxin-driven oncogenesis: implications for the microbiome–cancer targetome
Tanya M. Monaghan, Christos Polytarchou, Maria Hatziapostolou, Abdolrahman S. Nateri
2026, 2(5): e052. DOI: 10.48130/targetome-0026-0051
Exposure to multiple drugs with actionable pharmacogenetic biomarkers among older adults in China: a retrospective analysis
Xiaowen Hu, Yuxuan Zhao, Xue Wang, Gengchen Wang, Xinyi Zhang, Wenliang Dong, Luwen Shi, Christine Y. Lu, Xiaodong Guan, Xiaoyan Nie
2026, 2(5): e044. DOI: 10.48130/targetome-0026-0043